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Towards better models and mechanistic biomarkers for drug-induced gastrointes...
Adverse drug reactions affecting the gastrointestinal (GI) tract are a serious burden on patients, healthcare providers and the pharmaceutical industry. GI toxicity encompasses... -
MDH1 and MPP7 Regulate Autophagy in Pancreatic Ductal Adenocarcinoma
Pancreatic ductal adenocarcinoma (PDAC) is driven by metabolic changes in pancreatic cells caused by oncogenic mutations and dysregulation of p53. PDAC cell lines and... -
Network Biology Approaches to Identify Molecular and Systems-Level Difference...
The field of systems biology endeavors to map, study, and simulate cellular systems and their underlying mechanisms. The internal mechanisms of biological systems can be... -
SignaLink: Multilayered Regulatory Networks
Biological networks are graphs used to represent the inner workings of a biological system. Networks describe the relationships of the elements of biological systems using edges... -
The use of quantitative imaging to investigate regulators of membrane traffic...
Expansion of gene families facilitates robustness and evolvability of biological processes but impedes functional genetic dissection of signalling pathways. To address this,... -
The transcriptional landscape of polyploid wheat
The coordinated expression of highly related homoeologous genes in polyploid species underlies the phenotypes of many of the world’s major crops. Here we combine extensive gene... -
Evaluation of gene expression of different molecular biomarkers of stress res...
The paper reports the results of a laboratory test on the bioaccumulation and toxicological effects of sub-lethal soil concentration of copper, a widely used fungicide in... -
Rapid profiling of the preterm infant gut microbiota using nanopore sequencin...
The Oxford Nanopore MinION sequencing platform offers near real time analysis of DNA reads as they are generated, which makes the device attractive for in-field or clinical... -
Transcriptional and environmental control of bacterial denitrification and N2...
In oxygen-limited environments, denitrifying bacteria can switch from oxygen-dependent respiration to nitrate (NO3−) respiration in which the NO3− is sequentially reduced via... -
Unraveling the subtleties of β-(1→3)-glucan phosphorylase specificity in the ...
Glycoside phosphorylases (GPs) catalyze the phosphorolysis of glycans into the corresponding sugar 1-phosphates and shortened glycan chains. Given the diversity of natural... -
BioCIDER: a Contextualisation InDEx for biological Resources discovery
The vast, uncoordinated proliferation of bioinformatics resources (databases, software tools, training materials etc.) makes it difficult for users to find them. To facilitate...
