Towards better models and mechanistic biomarkers for drug-induced gastrointestinal injury

Adverse drug reactions affecting the gastrointestinal (GI) tract are a serious burden on patients, healthcare providers and the pharmaceutical industry. GI toxicity encompasses a range of pathologies in different parts of the GI tract. However, to date no specific mechanistic diagnostic/prognostic biomarkers or translatable pre-clinical models of GI toxicity exist. This review will cover the current knowledge of GI ADRs, existing biomarkers and models with potential application for toxicity screening/monitoring. We focus on the current gaps in our knowledge, the potential opportunities and recommend that a systematic approach is needed to identify mechanism-based GI biomarkers with potential for clinical translation.

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Author Carr, Daniel F.
Last Updated November 21, 2019, 17:33 (UTC)
Created August 1, 2019, 10:31 (UTC)
Article Is Open Access false
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DOI 10.1016/j.pharmthera.2017.01.002
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Journal Is Open Access false
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