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Exploring gene networks in two sunflower lines with contrasting leaf senescen...
Background Leaf senescence is a complex process, controlled by multiple genetic and environmental variables. In sunflower, leaf senescence is triggered abruptly following... -
CausalTAB: the PSI-MITAB 2.8 updated format for signalling data representatio...
Abstract Motivation Combining multiple layers of information underlying biological complexity into a structured framework represent a challenge in systems biology. A key... -
Long-read sequencing reveals the splicing profile of the calcium channel gene...
RNA splicing is a key mechanism linking genetic variation and complex diseases, including schizophrenia. Splicing profiles are particularly diverse in the brain, but it is... -
Genomic prediction unifies animal and plant breeding programs to form platfor...
The rate of annual yield increases for major staple crops must more than double relative to current levels in order to feed a predicted global population of 9 billion by 2050.... -
Community-Driven Data Analysis Training for Biology
The primary problem with the explosion of biomedical datasets is not the data itself, not computational resources, and not the required storage space, but the general lack of... -
A Galaxy-based training resource for single-cell RNA-seq quality control and ...
Background It is not a trivial step to move from single-cell RNA-seq (scRNA-seq) data production to data analysis. There is a lack of intuitive training materials and... -
Genetic Diversity and Gene Family Expansions in Members of the Genus Entamoeba
Amoebiasis is the third-most common cause of mortality worldwide from a parasitic disease. Although the primary etiological agent of amoebiasis is the obligate human parasite... -
Leveraging multiple transcriptome assembly methods for improved gene structur...
The performance of RNA-Seq aligners and assemblers varies greatly across different organisms and experiments, and often the optimal approach is not known beforehand. Here we... -
A modified sequence capture approach allowing standard and methylation analys...
Bread wheat has a large complex genome that makes whole genome resequencing costly. Therefore, genome complexity reduction techniques such as sequence capture make re-sequencing... -
A world of opportunities with nanopore sequencing
Oxford Nanopore Technologies' MinION sequencer was launched in pre-release form in 2014 and represents an exciting new sequencing paradigm. The device offers multi-kilobase... -
Bioconda: sustainable and comprehensive software distribution for the life sc...
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Identification of functional long non-coding RNAs in C. elegans
Functional characterisation of the compact genome of the model organism Caenorhabditis elegans remains incomplete despite its sequencing twenty years ago. The last decade of... -
Speed breeding in growth chambers and glasshouses for crop breeding and model...
To meet the challenge of feeding a growing population, breeders and scientists are continuously looking for ways to increase genetic gain in crop breeding. One way this can be... -
Hidden variation in polyploid wheat drives local adaptation
Wheat has been domesticated into a large number of agricultural environments and has a remarkable ability to adapt to diverse environments. To understand this process, we survey... -
Harnessing plant metabolic diversity
Advances in DNA sequencing and synthesis technologies in the twenty-first century are now making it possible to build large-scale pipelines for engineering plant natural product... -
MinION Analysis and Reference Consortium: Phase 2 data release and analysis o...
Long-read sequencing is rapidly evolving and reshaping the suite of opportunities for genomic analysis. For the MinION in particular, as both the platform and chemistry develop,... -
Opening options for material transfer
The Open Material Transfer Agreement is a material-transfer agreement that enables broader sharing and use of biological materials by biotechnology practitioners working within... -
Adaptation and conservation insights from the koala genome
The koala, the only extant species of the marsupial family Phascolarctidae, is classified as ‘vulnerable’ due to habitat loss and widespread disease. We sequenced the koala... -
Increased transcriptional and metabolic capacity for lipid metabolism in the ...
The human prostate gland comprises three distinct anatomical glandular zones, namely the peripheral, central and transitional zones. Although prostate cancer can arise... -
An improved assembly and annotation of the allohexaploid wheat genome identif...
Advances in genome sequencing and assembly technologies are generating many high-quality genome sequences, but assemblies of large, repeat-rich polyploid genomes, such as that...