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Rapid profiling of the preterm infant gut microbiota using nanopore sequencin...
The Oxford Nanopore MinION sequencing platform offers near real time analysis of DNA reads as they are generated, which makes the device attractive for in-field or clinical... -
Aequatus: An open-source homology browser
Phylogenetic information inferred from the study of homologous genes helps us to understand the evolution of genes and gene families, including the identification of ancestral... -
A Galaxy-based training resource for single-cell RNA-seq quality control and ...
Background It is not a trivial step to move from single-cell RNA-seq (scRNA-seq) data production to data analysis. There is a lack of intuitive training materials and... -
Hidden variation in polyploid wheat drives local adaptation
Wheat has been domesticated into a large number of agricultural environments and has a remarkable ability to adapt to diverse environments. To understand this process, we survey... -
Increased transcriptional and metabolic capacity for lipid metabolism in the ...
The human prostate gland comprises three distinct anatomical glandular zones, namely the peripheral, central and transitional zones. Although prostate cancer can arise... -
An improved assembly and annotation of the allohexaploid wheat genome identif...
Advances in genome sequencing and assembly technologies are generating many high-quality genome sequences, but assemblies of large, repeat-rich polyploid genomes, such as that... -
Genome Variation and Molecular Epidemiology of Salmonella enterica Serovar Ty...
Salmonella enterica serovar Typhimurium is one of approximately 2,500 distinct serovars of the genus Salmonella but is exceptional in its wide distribution in the environment,... -
Convergent gene loss in aquatic plants predicts new components of plant immun...
The transition of plants from sea to land sparked an arms race with pathogens. The increased susceptibility of land plants is largely thought to be due to their dependence on... -
Repeat associated mechanisms of genome evolution and function revealed by the...
Understanding the mechanisms driving lineage-specific evolution in both primates and rodents has been hindered by the lack of sister clades with a similar phylogenetic structure... -
Cerox1 and microRNA-488-3p noncoding RNAs jointly regulate mitochondrial comp...
To generate energy efficiently, the cell is uniquely challenged to co-ordinate the abundance of electron transport chain protein subunits expressed from both nuclear and... -
Rapid Diagnosis of Lower Respiratory Infection using Nanopore-based Clinical ...
Lower respiratory infections (LRIs) accounted for three million deaths worldwide in 2016, the leading infectious cause of mortality. The “gold standard” for investigation of... -
Independent assessment and improvement of wheat genome assemblies using Fosil...
The accurate sequencing and assembly of very large, often polyploid, genomes remain a challenging task, limiting long range sequence information and phased sequence variation... -
Efficient and accurate detection of splice junctions from RNAseq with Portcullis
Next generation sequencing (NGS) technologies enable rapid and cheap genome-wide transcriptome analysis, providing vital information about gene structure, transcript expression... -
Identification of master regulators in goblet cells and Paneth cells using tr...
Dysfunction of intestinal epithelial cells is often associated with severe gut pathologies, such as inflammatory bowel disease (IBD). Although transcriptional signatures of... -
A quantitative model for characterizing the evolutionary history of mammalian...
Characterizing the evolutionary history of a gene’s expression profile is a critical component for understanding the relationship between genotype, expression, and phenotype.... -
Sex-specific changes in the aphid DNA methylation landscape
Aphids present an ideal system to study epigenetics as they can produce diverse, but genetically identical, morphs in response to environmental stimuli. Here, using whole genome... -
Analysis of structural variants in four African Cichlids highlights an associ...
African Lakes Cichlids are one of the most impressive example of adaptive radiation. Independently in Lake Victoria, Tanganyika, and Malawi, several hundreds of species arose... -
Novel RNA Virus Genome Discovered in Ghost Ants ( Tapinoma melanocephalum ) f...
Here, we report the full-genome sequence of Milolii virus, a novel single-stranded (positive-sense) RNA virus discovered from Tapinoma melanocephalum ants in Hawaii. The genome... -
Identification of Euglena gracilisβ-1,3-glucan phosphorylase and establishmen...
Glycoside phosphorylases (EC 2.4.x.x) carry out the reversible phosphorolysis of glucan polymers, producing the corresponding sugar 1-phosphate and a shortened glycan chain....
