New approaches for assembly of short-read metagenomic data

In recent years, the use of longer-range read data combined with advances in assembly algorithms has stimulated big improvements in the contiguity and quality of genome assemblies. However, these advances have not directly transferred to metagenomic datasets, as assumptions made by the single genome assembly algorithms do not apply when assembling multiple genomes at varying levels of abundance. The development of dedicated assemblers for metagenomic data was a relatively late innovation and for many years, researchers had to make do using tools designed for single genomes. This has changed in the last few years and we have seen the emergence of a new type of tool built using different principles. In this review, we describe the challenges inherent in metagenomic assemblies and compare the different approaches taken by these novel assembly tools.

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Author Ayling, Martin
Last Updated November 20, 2019, 16:45 (UTC)
Created August 1, 2019, 10:28 (UTC)
Article Host Type publisher
Article Is Open Access true
Article License Type cc-by
Article Version Type publishedVersion
Citation Report https://scite.ai/reports/10.7287/peerj.preprints.27332v1
DOI 10.7287/peerj.preprints.27332v1
Date Last Updated 2019-05-12T12:27:24.190047
Evidence open (via page says license)
Funder code(s)
Journal Is Open Access false
Open Access Status hybrid
PDF URL https://peerj.com/preprints/27332.pdf
Publisher URL https://doi.org/10.7287/peerj.preprints.27332v1