Defining Cell Identity with Single-Cell Omics

Cells are a fundamental unit of life, and the ability to study the phenotypes and behaviors of individual cells is crucial to understanding the workings of complex biological systems. Cell phenotypes (epigenomic, transcriptomic, proteomic, and metabolomic) exhibit dramatic heterogeneity between and within the different cell types and states underlying cellular functional diversity. Cell genotypes can also display heterogeneity throughout an organism, in the form of somatic genetic variation—most notably in the emergence and evolution of tumors. Recent technical advances in single‐cell isolation and the development of omics approaches sensitive enough to reveal these aspects of cell identity have enabled a revolution in the study of multicellular systems. In this review, we discuss the technologies available to resolve the genomes, epigenomes, transcriptomes, proteomes, and metabolomes of single cells from a wide variety of living systems.

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Author Mincarelli, Laura
Last Updated November 20, 2019, 16:43 (UTC)
Created August 1, 2019, 10:29 (UTC)
Article Host Type publisher
Article Is Open Access true
Article License Type cc-by
Article Version Type publishedVersion
Citation Report https://scite.ai/reports/10.1002/pmic.201700312
DOI 10.1002/pmic.201700312
Date Last Updated 2019-06-19T18:54:28.973935
Evidence open (via page says license)
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Journal Is Open Access false
Open Access Status hybrid
PDF URL https://onlinelibrary.wiley.com/doi/pdf/10.1002/pmic.201700312
Publisher URL https://doi.org/10.1002/pmic.201700312