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DNA assembly standards: Setting the low-level programming code for plant biot...
Synthetic Biology is defined as the application of engineering principles to biology. It aims to increase the speed, ease and predictability with which desirable changes and... -
The evolutionary dynamics of microRNAs in domestic mammals
MiRNAs are crucial regulators of gene expression found across both the plant and animal kingdoms. While the number of annotated miRNAs deposited in miRBase has greatly increased... -
Towards better models and mechanistic biomarkers for drug-induced gastrointes...
Adverse drug reactions affecting the gastrointestinal (GI) tract are a serious burden on patients, healthcare providers and the pharmaceutical industry. GI toxicity encompasses... -
The use of quantitative imaging to investigate regulators of membrane traffic...
Expansion of gene families facilitates robustness and evolvability of biological processes but impedes functional genetic dissection of signalling pathways. To address this,... -
Evaluation of gene expression of different molecular biomarkers of stress res...
The paper reports the results of a laboratory test on the bioaccumulation and toxicological effects of sub-lethal soil concentration of copper, a widely used fungicide in... -
Genome-wide Analysis of Salmonella enterica serovar Typhi in Humanized Mice R...
Salmonella enterica serovar Typhi causes typhoid fever only in humans. Murine infection with S. Typhimurium is used as a typhoid model, but its relevance to human typhoid is... -
A four-group urine risk classifier for predicting outcomes in patients with p...
Objectives To develop a risk classifier using urine‐derived extracellular vesicle (EV)‐RNA capable of providing diagnostic information on disease status prior to biopsy, and... -
Tpz1TPP1 prevents telomerase activation and protects telomeres by modulating ...
In both mammalian and fission yeast cells, conserved shelterin and CST (CTC1-STN1-TEN1) complexes play critical roles in protection of telomeres and regulation of telomerase, an... -
Spatially resolved transcriptomics reveals plant host responses to pathogens
Background Thorough understanding of complex model systems requires the characterisation of processes in different cell types of an organism. This can be achieved with... -
Single cell ecology
Cells are the building blocks of life, from single-celled microbes through to multi-cellular organisms. To understand a multitude of biological processes we need to understand... -
SEPATH: benchmarking the search for pathogens in human tissue whole genome se...
Background Human tissue is increasingly being whole genome sequenced as we transition into an era of genomic medicine. With this arises the potential to detect sequences... -
Targeted interplay between bacterial pathogens and host autophagy
Due to the critical role played by autophagy in pathogen clearance, pathogens have developed diverse strategies to subvert it. Despite previous key findings of... -
NODULE INCEPTION Recruits the Lateral Root Developmental Program for Symbioti...
To overcome nitrogen deficiencies in the soil, legumes enter symbioses with rhizobial bacteria that convert atmospheric nitrogen into ammonium. Rhizobia are accommodated as... -
Exploring gene networks in two sunflower lines with contrasting leaf senescen...
Background Leaf senescence is a complex process, controlled by multiple genetic and environmental variables. In sunflower, leaf senescence is triggered abruptly following... -
Genomic prediction unifies animal and plant breeding programs to form platfor...
The rate of annual yield increases for major staple crops must more than double relative to current levels in order to feed a predicted global population of 9 billion by 2050.... -
Community-Driven Data Analysis Training for Biology
The primary problem with the explosion of biomedical datasets is not the data itself, not computational resources, and not the required storage space, but the general lack of... -
A modified sequence capture approach allowing standard and methylation analys...
Bread wheat has a large complex genome that makes whole genome resequencing costly. Therefore, genome complexity reduction techniques such as sequence capture make re-sequencing... -
A world of opportunities with nanopore sequencing
Oxford Nanopore Technologies' MinION sequencer was launched in pre-release form in 2014 and represents an exciting new sequencing paradigm. The device offers multi-kilobase... -
Bioconda: sustainable and comprehensive software distribution for the life sc...
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Speed breeding in growth chambers and glasshouses for crop breeding and model...
To meet the challenge of feeding a growing population, breeders and scientists are continuously looking for ways to increase genetic gain in crop breeding. One way this can be...
