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Comprehensive assembly and analysis of the transcriptome of maritime pine dev...
There are clear differences in embryo development between angiosperm and gymnosperm species. Most of the current knowledge on gene expression and regulation during plant embryo... -
MDH1 and MPP7 Regulate Autophagy in Pancreatic Ductal Adenocarcinoma
Pancreatic ductal adenocarcinoma (PDAC) is driven by metabolic changes in pancreatic cells caused by oncogenic mutations and dysregulation of p53. PDAC cell lines and... -
Rapid profiling of the preterm infant gut microbiota using nanopore sequencin...
The Oxford Nanopore MinION sequencing platform offers near real time analysis of DNA reads as they are generated, which makes the device attractive for in-field or clinical... -
Transcriptional and environmental control of bacterial denitrification and N2...
In oxygen-limited environments, denitrifying bacteria can switch from oxygen-dependent respiration to nitrate (NO3−) respiration in which the NO3− is sequentially reduced via... -
Unraveling the subtleties of β-(1→3)-glucan phosphorylase specificity in the ...
Glycoside phosphorylases (GPs) catalyze the phosphorolysis of glycans into the corresponding sugar 1-phosphates and shortened glycan chains. Given the diversity of natural... -
Aequatus: An open-source homology browser
Phylogenetic information inferred from the study of homologous genes helps us to understand the evolution of genes and gene families, including the identification of ancestral... -
An Ultra High-Density Arabidopsis thaliana Crossover Map That Refines the Inf...
Many environmental, genetic, and epigenetic factors are known to affect the frequency and positioning of meiotic crossovers (COs). Suppression of COs by large, cytologically... -
Long-read sequencing reveals the splicing profile of the calcium channel gene...
RNA splicing is a key mechanism linking genetic variation and complex diseases, including schizophrenia. Splicing profiles are particularly diverse in the brain, but it is... -
A Galaxy-based training resource for single-cell RNA-seq quality control and ...
Background It is not a trivial step to move from single-cell RNA-seq (scRNA-seq) data production to data analysis. There is a lack of intuitive training materials and... -
Identification of functional long non-coding RNAs in C. elegans
Functional characterisation of the compact genome of the model organism Caenorhabditis elegans remains incomplete despite its sequencing twenty years ago. The last decade of... -
Hidden variation in polyploid wheat drives local adaptation
Wheat has been domesticated into a large number of agricultural environments and has a remarkable ability to adapt to diverse environments. To understand this process, we survey... -
Increased transcriptional and metabolic capacity for lipid metabolism in the ...
The human prostate gland comprises three distinct anatomical glandular zones, namely the peripheral, central and transitional zones. Although prostate cancer can arise... -
An improved assembly and annotation of the allohexaploid wheat genome identif...
Advances in genome sequencing and assembly technologies are generating many high-quality genome sequences, but assemblies of large, repeat-rich polyploid genomes, such as that... -
Developmentally regulated autophagy is required for eye formation in Drosophila
The compound eye of the fruit fly Drosophila melanogaster is one of the most intensively studied and best understood model organs in the field of developmental genetics. Herein... -
SPECTRE: a Suite of PhylogEnetiC Tools for Reticulate Evolution
Split-networks are a generalization of phylogenetic trees that have proven to be a powerful tool in phylogenetics. Various ways have been developed for computing such networks,... -
Genome Variation and Molecular Epidemiology of Salmonella enterica Serovar Ty...
Salmonella enterica serovar Typhimurium is one of approximately 2,500 distinct serovars of the genus Salmonella but is exceptional in its wide distribution in the environment,... -
Convergent gene loss in aquatic plants predicts new components of plant immun...
The transition of plants from sea to land sparked an arms race with pathogens. The increased susceptibility of land plants is largely thought to be due to their dependence on... -
Repeat associated mechanisms of genome evolution and function revealed by the...
Understanding the mechanisms driving lineage-specific evolution in both primates and rodents has been hindered by the lack of sister clades with a similar phylogenetic structure... -
Cerox1 and microRNA-488-3p noncoding RNAs jointly regulate mitochondrial comp...
To generate energy efficiently, the cell is uniquely challenged to co-ordinate the abundance of electron transport chain protein subunits expressed from both nuclear and... -
Rapid Diagnosis of Lower Respiratory Infection using Nanopore-based Clinical ...
Lower respiratory infections (LRIs) accounted for three million deaths worldwide in 2016, the leading infectious cause of mortality. The “gold standard” for investigation of...
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