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The evolutionary dynamics of microRNAs in domestic mammals
MiRNAs are crucial regulators of gene expression found across both the plant and animal kingdoms. While the number of annotated miRNAs deposited in miRBase has greatly increased... -
A gene expression signature in developing Purkinje cells predicts autism and ...
Autism spectrum disorder (ASD) is a complex neurodevelopmental disease whose underpinning molecular mechanisms and neural substrates are subject to intense scrutiny.... -
Exploiting the ZIP4 homologue within the wheat Ph1 locus has identified two l...
Despite possessing related ancestral genomes, hexaploid wheat behaves as a diploid during meiosis. The wheat Ph1 locus promotes accurate synapsis and crossover of homologous... -
Integrative analysis of Paneth cell proteomic and transcriptomic data from in...
Paneth cells are key epithelial cells that provide an antimicrobial barrier and maintain integrity of the small-intestinal stem cell niche. Paneth cell abnormalities are... -
SalmoNet, an integrated network of ten Salmonella enterica strains reveals co...
Salmonella enterica is a prominent bacterial pathogen with implications on human and animal health. Salmonella serovars could be classified as gastro-intestinal or... -
Genomics of habitat choice and adaptive evolution in a deep-sea fish
Intraspecific diversity promotes evolutionary change, and when partitioned among geographic regions or habitats can form the basis for speciation. Marine species live in an... -
Interplay of cis and trans mechanisms driving transcription factor binding an...
Noncoding regulatory variants play a central role in the genetics of human diseases and in evolution. Here we measure allele-specific transcription factor binding occupancy of... -
VERNALIZATION1 controls developmental responses of winter wheat under high am...
Low temperatures are required to regulate the transition from vegetative to reproductive growth via a pathway called vernalization. In wheat, vernalization predominantly... -
Primula vulgaris (primrose) genome assembly, annotation and gene expression, ...
Primula vulgaris (primrose) exhibits heterostyly: plants produce self-incompatible pin- or thrum-form flowers, with anthers and stigma at reciprocal heights. Darwin concluded... -
Harnessing genetic potential of wheat germplasm banks through impact-oriented...
The value of exotic wheat genetic resources for accelerating grain yield gains is largely unproven and unrealized. We used next-generation sequencing, together with...
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