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The evolutionary dynamics of microRNAs in domestic mammals
MiRNAs are crucial regulators of gene expression found across both the plant and animal kingdoms. While the number of annotated miRNAs deposited in miRBase has greatly increased... -
SignaLink: Multilayered Regulatory Networks
Biological networks are graphs used to represent the inner workings of a biological system. Networks describe the relationships of the elements of biological systems using edges... -
Evaluation of gene expression of different molecular biomarkers of stress res...
The paper reports the results of a laboratory test on the bioaccumulation and toxicological effects of sub-lethal soil concentration of copper, a widely used fungicide in... -
Tpz1TPP1 prevents telomerase activation and protects telomeres by modulating ...
In both mammalian and fission yeast cells, conserved shelterin and CST (CTC1-STN1-TEN1) complexes play critical roles in protection of telomeres and regulation of telomerase, an... -
Spatially resolved transcriptomics reveals plant host responses to pathogens
Background Thorough understanding of complex model systems requires the characterisation of processes in different cell types of an organism. This can be achieved with... -
SEPATH: benchmarking the search for pathogens in human tissue whole genome se...
Background Human tissue is increasingly being whole genome sequenced as we transition into an era of genomic medicine. With this arises the potential to detect sequences... -
Exploring gene networks in two sunflower lines with contrasting leaf senescen...
Background Leaf senescence is a complex process, controlled by multiple genetic and environmental variables. In sunflower, leaf senescence is triggered abruptly following... -
Genomic prediction unifies animal and plant breeding programs to form platfor...
The rate of annual yield increases for major staple crops must more than double relative to current levels in order to feed a predicted global population of 9 billion by 2050.... -
A modified sequence capture approach allowing standard and methylation analys...
Bread wheat has a large complex genome that makes whole genome resequencing costly. Therefore, genome complexity reduction techniques such as sequence capture make re-sequencing... -
A world of opportunities with nanopore sequencing
Oxford Nanopore Technologies' MinION sequencer was launched in pre-release form in 2014 and represents an exciting new sequencing paradigm. The device offers multi-kilobase... -
Bioconda: sustainable and comprehensive software distribution for the life sc...
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Speed breeding in growth chambers and glasshouses for crop breeding and model...
To meet the challenge of feeding a growing population, breeders and scientists are continuously looking for ways to increase genetic gain in crop breeding. One way this can be... -
Opening options for material transfer
The Open Material Transfer Agreement is a material-transfer agreement that enables broader sharing and use of biological materials by biotechnology practitioners working within... -
Adaptation and conservation insights from the koala genome
The koala, the only extant species of the marsupial family Phascolarctidae, is classified as ‘vulnerable’ due to habitat loss and widespread disease. We sequenced the koala... -
Experimental evidence for rapid genomic adaptation to a new niche in an adapt...
A substantial part of biodiversity is thought to have arisen from adaptive radiations in which one lineage rapidly diversified into multiple lineages specialized to many... -
Integration of transcriptomic and metabolic data reveals hub transcription fa...
Drought is one of the most important environmental stresses that effects crop productivity in many agricultural regions. Sunflower is tolerant to drought conditions but the... -
A gene expression signature in developing Purkinje cells predicts autism and ...
Autism spectrum disorder (ASD) is a complex neurodevelopmental disease whose underpinning molecular mechanisms and neural substrates are subject to intense scrutiny.... -
Exploiting the ZIP4 homologue within the wheat Ph1 locus has identified two l...
Despite possessing related ancestral genomes, hexaploid wheat behaves as a diploid during meiosis. The wheat Ph1 locus promotes accurate synapsis and crossover of homologous... -
A chromosome conformation capture ordered sequence of the barley genome
The International Barley Genome Sequencing Consortium reports sequencing and assembly of a reference genome for barley, Hordeum vulgare. -
Plant metabolic engineering in the synthetic biology era: plant chassis selec...
In the July 2017 Gordon Research Conference on Plant Metabolic Engineering that was held in Waterville Valley, New Hampshire, an intriguing discussion began. This discussion...
