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Rapid Diagnosis of Lower Respiratory Infection using Nanopore-based Clinical ...
Lower respiratory infections (LRIs) accounted for three million deaths worldwide in 2016, the leading infectious cause of mortality. The “gold standard” for investigation of... -
Leaf-GP: an open and automated software application for measuring growth phen...
Background Plants demonstrate dynamic growth phenotypes that are determined by genetic and environmental factors. Phenotypic analysis of growth features over time is a key... -
Independent assessment and improvement of wheat genome assemblies using Fosil...
The accurate sequencing and assembly of very large, often polyploid, genomes remain a challenging task, limiting long range sequence information and phased sequence variation... -
Efficient and accurate detection of splice junctions from RNAseq with Portcullis
Next generation sequencing (NGS) technologies enable rapid and cheap genome-wide transcriptome analysis, providing vital information about gene structure, transcript expression... -
Identification of master regulators in goblet cells and Paneth cells using tr...
Dysfunction of intestinal epithelial cells is often associated with severe gut pathologies, such as inflammatory bowel disease (IBD). Although transcriptional signatures of... -
A quantitative model for characterizing the evolutionary history of mammalian...
Characterizing the evolutionary history of a gene’s expression profile is a critical component for understanding the relationship between genotype, expression, and phenotype.... -
Chromosome assembly of large and complex genomes using multiple references
Despite the rapid development of sequencing technologies, the assembly of mammalian-scale genomes into complete chromosomes remains one of the most challenging problems in... -
Sex-specific changes in the aphid DNA methylation landscape
Aphids present an ideal system to study epigenetics as they can produce diverse, but genetically identical, morphs in response to environmental stimuli. Here, using whole genome... -
Analysis of structural variants in four African Cichlids highlights an associ...
African Lakes Cichlids are one of the most impressive example of adaptive radiation. Independently in Lake Victoria, Tanganyika, and Malawi, several hundreds of species arose... -
Novel RNA Virus Genome Discovered in Ghost Ants ( Tapinoma melanocephalum ) f...
Here, we report the full-genome sequence of Milolii virus, a novel single-stranded (positive-sense) RNA virus discovered from Tapinoma melanocephalum ants in Hawaii. The genome... -
Identification of Euglena gracilisβ-1,3-glucan phosphorylase and establishmen...
Glycoside phosphorylases (EC 2.4.x.x) carry out the reversible phosphorolysis of glucan polymers, producing the corresponding sugar 1-phosphate and a shortened glycan chain.... -
Comparative genomic analysis of the ‘pseudofungus’ Hyphochytrium catenoides
Eukaryotic microbes have three primary mechanisms for obtaining nutrients and energy: phagotrophy, photosynthesis and osmotrophy. Traits associated with the latter two functions...
