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The evolutionary dynamics of microRNAs in domestic mammals
MiRNAs are crucial regulators of gene expression found across both the plant and animal kingdoms. While the number of annotated miRNAs deposited in miRBase has greatly increased... -
Tpz1TPP1 prevents telomerase activation and protects telomeres by modulating ...
In both mammalian and fission yeast cells, conserved shelterin and CST (CTC1-STN1-TEN1) complexes play critical roles in protection of telomeres and regulation of telomerase, an... -
Spatially resolved transcriptomics reveals plant host responses to pathogens
Background Thorough understanding of complex model systems requires the characterisation of processes in different cell types of an organism. This can be achieved with... -
SEPATH: benchmarking the search for pathogens in human tissue whole genome se...
Background Human tissue is increasingly being whole genome sequenced as we transition into an era of genomic medicine. With this arises the potential to detect sequences... -
Exploring gene networks in two sunflower lines with contrasting leaf senescen...
Background Leaf senescence is a complex process, controlled by multiple genetic and environmental variables. In sunflower, leaf senescence is triggered abruptly following... -
A modified sequence capture approach allowing standard and methylation analys...
Bread wheat has a large complex genome that makes whole genome resequencing costly. Therefore, genome complexity reduction techniques such as sequence capture make re-sequencing... -
MinION Analysis and Reference Consortium: Phase 2 data release and analysis o...
Long-read sequencing is rapidly evolving and reshaping the suite of opportunities for genomic analysis. For the MinION in particular, as both the platform and chemistry develop,... -
Omics Approaches to Identify Potential Biomarkers of Inflammatory Diseases in...
Inflammatory diseases such as inflammatory bowel disease (IBD) require recurrent invasive tests, including blood tests, radiology, and endoscopic evaluation both to diagnose and... -
A gene expression signature in developing Purkinje cells predicts autism and ...
Autism spectrum disorder (ASD) is a complex neurodevelopmental disease whose underpinning molecular mechanisms and neural substrates are subject to intense scrutiny.... -
Introducing the Brassica Information Portal: Towards integrating genotypic an...
The Brassica Information Portal (BIP) is a centralised repository for Brassica phenotypic data. Trait data associated with Brassica research and breeding experiments conducted... -
Coordination of robust single cell rhythms in the Arabidopsis circadian clock...
The Arabidopsis circadian clock orchestrates gene regulation across the day/night cycle. Although a multiple feedback loop circuit has been shown to generate the 24-hr rhythm,... -
SalmoNet, an integrated network of ten Salmonella enterica strains reveals co...
Salmonella enterica is a prominent bacterial pathogen with implications on human and animal health. Salmonella serovars could be classified as gastro-intestinal or... -
Building a locally diploid genome and transcriptome of the diatom Fragilariop...
Building a locally diploid genome and transcriptome of the diatom Fragilariopsis cylindrus -
Elucidating the genetic basis of biomass accumulation and radiation use effic...
One of the major challenges for plant scientists is increasing wheat (Triticum aestivum) yield potential (YP). A significant bottleneck for increasing YP is achieving increased... -
Interplay of cis and trans mechanisms driving transcription factor binding an...
Noncoding regulatory variants play a central role in the genetics of human diseases and in evolution. Here we measure allele-specific transcription factor binding occupancy of... -
A transatlantic perspective on 20 emerging issues in biological engineering
Advances in biological engineering are likely to have substantial impacts on global society. To explore these potential impacts we ran a horizon scanning exercise to capture a... -
Primula vulgaris (primrose) genome assembly, annotation and gene expression, ...
Primula vulgaris (primrose) exhibits heterostyly: plants produce self-incompatible pin- or thrum-form flowers, with anthers and stigma at reciprocal heights. Darwin concluded... -
Harnessing genetic potential of wheat germplasm banks through impact-oriented...
The value of exotic wheat genetic resources for accelerating grain yield gains is largely unproven and unrealized. We used next-generation sequencing, together with...
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