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Heterarchy of transcription factors driving basal and luminal cell phenotypes...
Heterarchy of transcription factors driving basal and luminal cell phenotypes in human urothelium -
Speed breeding is a powerful tool to accelerate crop research and breeding
The growing human population and a changing environment have raised significant concern for global food security, with the current improvement rate of several important crops... -
SalmoNet, an integrated network of ten Salmonella enterica strains reveals co...
Salmonella enterica is a prominent bacterial pathogen with implications on human and animal health. Salmonella serovars could be classified as gastro-intestinal or... -
Zinc finger nuclease-mediated precision genome editing of an endogenous gene ...
Sequence‐specific nucleases have been used to engineer targeted genome modifications in various plants. While targeted gene knockouts resulting in loss of function have been... -
Genomics of habitat choice and adaptive evolution in a deep-sea fish
Intraspecific diversity promotes evolutionary change, and when partitioned among geographic regions or habitats can form the basis for speciation. Marine species live in an... -
New approaches for assembly of short-read metagenomic data
In recent years, the use of longer-range read data combined with advances in assembly algorithms has stimulated big improvements in the contiguity and quality of genome... -
Building a locally diploid genome and transcriptome of the diatom Fragilariop...
Building a locally diploid genome and transcriptome of the diatom Fragilariopsis cylindrus -
Elucidating the genetic basis of biomass accumulation and radiation use effic...
One of the major challenges for plant scientists is increasing wheat (Triticum aestivum) yield potential (YP). A significant bottleneck for increasing YP is achieving increased... -
Practical Computational Reproducibility in the Life Sciences
AUTHOR CONTRIBUTIONS -
Sixteen diverse laboratory mouse reference genomes define strain-specific hap...
We report full-length draft de novo genome assemblies for 16 widely used inbred mouse strains and find extensive strain-specific haplotype variation. We identify and... -
Biodiversity-function relationships in methanogenic communities
Methanogenic communities play a crucial role in carbon cycling and biotechnology (anaerobic digestion), but our understanding of how their diversity, or composition in general,... -
The ash dieback invasion of Europe was founded by two genetically divergent i...
Accelerating international trade and climate change make pathogen spread an increasing concern. Hymenoscyphus fraxineus, the causal agent of ash dieback, is a fungal pathogen... -
Interplay of cis and trans mechanisms driving transcription factor binding an...
Noncoding regulatory variants play a central role in the genetics of human diseases and in evolution. Here we measure allele-specific transcription factor binding occupancy of... -
A transatlantic perspective on 20 emerging issues in biological engineering
Advances in biological engineering are likely to have substantial impacts on global society. To explore these potential impacts we ran a horizon scanning exercise to capture a... -
Defining Cell Identity with Single-Cell Omics
Cells are a fundamental unit of life, and the ability to study the phenotypes and behaviors of individual cells is crucial to understanding the workings of complex biological... -
Plant genetic resources for food and agriculture: opportunities and challenge...
Over the last decade, there has been an ongoing revolution in the exploration, manipulation and synthesis of biological systems, through the development of new technologies that... -
Primula vulgaris (primrose) genome assembly, annotation and gene expression, ...
Primula vulgaris (primrose) exhibits heterostyly: plants produce self-incompatible pin- or thrum-form flowers, with anthers and stigma at reciprocal heights. Darwin concluded... -
Harnessing genetic potential of wheat germplasm banks through impact-oriented...
The value of exotic wheat genetic resources for accelerating grain yield gains is largely unproven and unrealized. We used next-generation sequencing, together with... -
Finding a partner in the ocean: molecular and evolutionary bases of the respo...
Microalgae play a major role as primary producers in aquatic ecosystems. Cell signalling regulates their interactions with the environment and other organisms, yet this process...
